Azra Raza Selected Research

gamma-Glu-S-BzCys-PhGly diethyl ester (T.199)

4/2010	Oral Ezatiostat HCl (TLK199) and Myelodysplastic syndrome: a case report of sustained hematologic response following an abbreviated exposure.
6/2009	Phase 1 multicenter dose-escalation study of ezatiostat hydrochloride (TLK199 tablets), a novel glutathione analog prodrug, in patients with myelodysplastic syndrome.
5/2009	Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra, TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome.

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Azra Raza Research Topics

Disease

40	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2021 - 01/2000
14	Neoplasms (Cancer) 04/2022 - 01/2000
12	Anemia 01/2022 - 03/2006
9	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 04/2006
8	Primary Myelofibrosis (Myelosclerosis) 01/2017 - 01/2009
6	Leukemia 01/2022 - 02/2008
6	Chromosome Aberrations (Chromosome Abnormalities) 02/2014 - 10/2006
5	Thrombocytopenia (Thrombopenia) 04/2015 - 10/2006
4	Disease Progression 01/2017 - 03/2006
4	Diarrhea 01/2017 - 04/2012
3	Splenomegaly 01/2017 - 02/2014
3	Fatigue 01/2017 - 04/2012
3	Refractory Anemia 12/2016 - 03/2006
3	Nausea 01/2016 - 04/2012
3	Neutropenia 04/2012 - 03/2006
3	Chromosome 5q Deletion Syndrome 10/2011 - 01/2008
3	Cytopenia 12/2008 - 03/2002
2	Residual Neoplasm 11/2019 - 07/2008
2	Infections 01/2016 - 03/2006
2	Hemolysis 05/2014 - 10/2013
2	Uniparental Disomy 12/2012 - 01/2010
1	Polyploidy 04/2022
1	Sepsis (Septicemia) 01/2017
1	Pneumonia (Pneumonitis) 01/2017
1	Pancreatic Neoplasms (Pancreatic Cancer) 07/2016
1	Exanthema (Rash) 01/2016
1	Genomic Instability 01/2016
1	Dysuria 06/2015
1	Hematuria 06/2015
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/2014
1	Ataxia (Dyssynergia) 01/2014
1	Sleepiness 01/2014
1	Confusion (Bewilderment) 01/2014
1	Hematologic Neoplasms (Hematological Malignancy) 04/2012
1	Vomiting 04/2012

Drug/Important Bio-Agent (IBA)

8	Lenalidomide (CC 5013)FDA Link 04/2012 - 08/2005
6	Thalidomide (Thalomid)FDA Link 08/2012 - 08/2004
5	ruxolitinibIBA 01/2017 - 03/2012
4	Pharmaceutical PreparationsIBA 06/2015 - 07/2007
3	Proteins (Proteins, Gene)FDA Link 10/2019 - 01/2009
3	DNA (Deoxyribonucleic Acid)IBA 06/2015 - 03/2002
3	Ribosomal Proteins (Ribosomal Protein)IBA 12/2012 - 01/2008
3	Glutathione Transferase (Glutathione S-Transferase)IBA 04/2012 - 05/2009
3	Decitabine FDA Link 08/2010 - 04/2006
3	Azacitidine (5 Azacytidine)FDA Link 08/2010 - 04/2007
3	gamma-Glu-S-BzCys-PhGly diethyl ester (T.199)IBA 04/2010 - 05/2009
3	Biological ProductsIBA 01/2008 - 04/2002
2	Serotonin (5 Hydroxytryptamine)IBA 01/2022 - 10/2014
2	Serotonin ReceptorsIBA 01/2022 - 10/2014
2	RNA Splicing FactorsIBA 12/2016 - 01/2016
2	Hemoglobins (Hemoglobin)IBA 01/2016 - 12/2014
2	ON 01910IBA 06/2015 - 08/2013
2	Janus Kinase 1IBA 04/2015 - 12/2013
2	obatoclaxIBA 12/2014 - 01/2014
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 05/2014 - 10/2013
2	Janus Kinase InhibitorsIBA 02/2014 - 05/2013
2	Janus Kinase 2IBA 12/2013 - 08/2012
2	MicroRNAs (MicroRNA)IBA 05/2013 - 10/2011
2	Dexamethasone (Maxidex)FDA LinkGeneric 08/2012 - 01/2000
2	Arsenic Trioxide (Trisenox)FDA Link 08/2012 - 08/2004
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2012 - 12/2008
2	ProdrugsIBA 06/2009 - 05/2009
2	Glutathione (Reduced Glutathione)IBA 06/2009 - 05/2009
2	CytokinesIBA 12/2004 - 04/2002
1	Phosphotransferases (Kinase)IBA 01/2022
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 01/2022
1	Serum Amyloid A Protein (Serum Amyloid A)IBA 01/2022
1	EnzymesIBA 01/2022
1	KynurenineIBA 01/2022
1	HematinicsIBA 01/2021
1	imetelstatIBA 01/2021
1	AntigensIBA 11/2019
1	Immunoconjugates (Immunoconjugate)IBA 11/2019
1	Chimeric Antigen ReceptorsIBA 11/2019
1	CarcinogensIBA 10/2018
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2016
1	U2 small nuclear RNA (U2 snRNA)IBA 01/2016
1	trametinibIBA 01/2016
1	Alanine Transaminase (SGPT)IBA 01/2016
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2016
1	Mitogen-Activated Protein KinasesIBA 01/2016
1	MAP Kinase Kinase 1IBA 01/2016
1	MethyltransferasesIBA 06/2015
1	Hormones (Hormone)IBA 10/2014
1	CateninsIBA 02/2014
1	Phenylalanine (L-Phenylalanine)FDA Link 08/2012
1	Codon (Codons)IBA 08/2012
1	Valine (L-Valine)FDA Link 08/2012
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 08/2012
1	DioxygenasesIBA 08/2012
1	IronIBA 06/2012
1	Ferritins (Ferritin)IBA 06/2012
1	Deferasirox FDA Link 06/2012

Therapy/Procedure

19	Therapeutics 04/2022 - 01/2000
3	Drug Therapy (Chemotherapy) 07/2016 - 07/2008
1	Immunotherapy 11/2019
1	Transplantation 11/2019
1	Erythrocyte Transfusion 01/2017
1	Radiotherapy 07/2016
1	Infusion Pumps (Infusion Pump) 06/2015